Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC004
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-11 15:20
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient madopar 3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 5, 'TN': 5, 'TP': 37, 'FP': 25}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 22, 'TP': 15, 'FP': 8}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 24, 'TN': 16, 'TP': 18, 'FP': 14}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 9.756
timePerCircleCoV 0.151208
timePerCircleSlope -0.0454483
meanError 1.36478
tremorFreq 5.37109
tremorRelPower 29.7879
tremorGyroAmpMean 0.0154588
tremorGyroAmpSlope -0.00277183
tremorGyroAmpCoV 0.267876
tremorCoordAmpMean 0.0482623
tremorCoordAmpSlope -0.00247291
tremorCoordAmpCoV 0.293459
tremorAccAmpMean 0.0383868
tremorAccAmpSlope -0.00215727
tremorAccAmpCoV 0.316488
tremorPcRelVar 0.757464
tremorPcX -0.603447
tremorPcY 0.797403

Circle Segment 1

Duration 11.48 s, Accuracy Estimate 1.721 (lower is better)

Circle Segment 2

Duration 10.48 s, Accuracy Estimate 1.695 (lower is better)

Circle Segment 3

Duration 11.88 s, Accuracy Estimate 1.38 (lower is better)

Circle Segment 4

Duration 10.24 s, Accuracy Estimate 1.259 (lower is better)

Circle Segment 5

Duration 9.64 s, Accuracy Estimate 1.135 (lower is better)

Circle Segment 6

Duration 10.2 s, Accuracy Estimate 1.35 (lower is better)

Circle Segment 7

Duration 9.84 s, Accuracy Estimate 1.052 (lower is better)

Circle Segment 8

Duration 8.72 s, Accuracy Estimate 0.917 (lower is better)

Circle Segment 9

Duration 7.88 s, Accuracy Estimate 1.251 (lower is better)

Circle Segment 10

Duration 7.2 s, Accuracy Estimate 1.888 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 26.808
timePerSpiralCoV 0.0959224
timePerSpiralSlope -0.0265683
meanError 1.52953
tremorFreq 6.44531
tremorRelPower 30.3186
tremorGyroAmpMean 0.0141469
tremorGyroAmpSlope 0.00050566
tremorGyroAmpCoV 0.401932
tremorCoordAmpMean 0.0377333
tremorCoordAmpSlope 0.000575256
tremorCoordAmpCoV 0.310058
tremorAccAmpMean 0.0333079
tremorAccAmpSlope 0.000488661
tremorAccAmpCoV 0.297166
tremorPcRelVar 0.735974
tremorPcX 0.545042
tremorPcY -0.838409

Spiral Segment 1

Duration 31.68 s, Accuracy Estimate 1.535 (lower is better)

Spiral Segment 2

Duration 30.56 s, Accuracy Estimate 1.376 (lower is better)

Spiral Segment 3

Duration 27.76 s, Accuracy Estimate 1.507 (lower is better)

Spiral Segment 4

Duration 25.44 s, Accuracy Estimate 1.44 (lower is better)

Spiral Segment 5

Duration 26.84 s, Accuracy Estimate 1.656 (lower is better)

Spiral Segment 6

Duration 25.12 s, Accuracy Estimate 1.681 (lower is better)

Spiral Segment 7

Duration 25.0 s, Accuracy Estimate 1.641 (lower is better)

Spiral Segment 8

Duration 27.0 s, Accuracy Estimate 1.522 (lower is better)

Spiral Segment 9

Duration 24.88 s, Accuracy Estimate 1.558 (lower is better)

Spiral Segment 10

Duration 23.8 s, Accuracy Estimate 1.379 (lower is better)

Elel

eDurationMean 0.614872
eDurationStd 0.304971
eDurationStdnorm 0.495991
eDurationMedian 0.515
eDurationQuartdelta 0.1875
eDurationQuartdeltanorm 0.364078
eDurationKurt 9.60661
eDurationTrenddiff -0.085
eDurationTrendratio 0.850877
eWidthMean 3.87
eWidthStd 1.17748
eWidthStdnorm 0.304259
eWidthMedian 3.51
eWidthQuartdelta 1.872
eWidthQuartdeltanorm 0.533333
eWidthKurt 2.1062
eWidthTrenddiff -0.117
eWidthTrendratio 0.966667
eHeightMean 8.235
eHeightStd 2.00049
eHeightStdnorm 0.242925
eHeightMedian 7.839
eHeightQuartdelta 3.2175
eHeightQuartdeltanorm 0.410448
eHeightKurt 2.49938
eHeightTrenddiff -0.234
eHeightTrendratio 0.970149
eAspectMean 0.4745
eAspectStd 0.11126
eAspectStdnorm 0.234478
eAspectMedian 0.463415
eAspectQuartdelta 0.135278
eAspectQuartdeltanorm 0.291915
eAspectKurt 5.54969
eAspectTrenddiff -0.0439276
eAspectTrendratio 0.910053
eSlantMean 0.101783
eSlantStd 0.126442
eSlantStdnorm 1.24227
eSlantMedian 0.0923077
eSlantQuartdelta 0.157615
eSlantQuartdeltanorm 1.70749
eSlantKurt 6.22241
eSlantTrenddiff 0.00973888
eRtopMean 0.83558
eRtopStd 0.12211
eRtopStdnorm 0.146138
eRtopMedian 0.869565
eRtopQuartdelta 0.11025
eRtopQuartdeltanorm 0.126787
eRtopKurt 8.59266
eRtopTrenddiff 0.0490196
eRbotMean 0.629833
eRbotStd 0.198099
eRbotStdnorm 0.314527
eRbotMedian 0.625
eRbotQuartdelta 0.320601
eRbotQuartdeltanorm 0.512962
eRbotKurt 2.56593
eRbotTrenddiff 0.00657895
eRrightMean 0.919765
eRrightStd 0.0431166
eRrightStdnorm 0.0468778
eRrightMedian 0.929412
eRrightQuartdelta 0.051305
eRrightQuartdeltanorm 0.0552016
eRrightKurt 3.6927
eRrightTrenddiff -0.00348584
eRleftMean 0.311092
eRleftStd 0.114839
eRleftStdnorm 0.369148
eRleftMedian 0.3
eRleftQuartdelta 0.155338
eRleftQuartdeltanorm 0.517794
eRleftKurt 3.05635
eRleftTrenddiff -0.00507357
lDurationMean 0.754615
lDurationStd 0.31434
lDurationStdnorm 0.416557
lDurationMedian 0.65
lDurationQuartdelta 0.22125
lDurationQuartdeltanorm 0.340385
lDurationKurt 7.2358
lDurationTrenddiff -0.22
lDurationTrendratio 0.725
lWidthMean 7.857
lWidthStd 2.01322
lWidthStdnorm 0.256233
lWidthMedian 7.605
lWidthQuartdelta 3.2175
lWidthQuartdeltanorm 0.423077
lWidthKurt 2.44275
lWidthTrenddiff -2.34
lWidthTrendratio 0.72973
lHeightMean 19.287
lHeightStd 3.2947
lHeightStdnorm 0.170825
lHeightMedian 19.305
lHeightQuartdelta 5.148
lHeightQuartdeltanorm 0.266667
lHeightKurt 2.46871
lHeightTrenddiff -2.691
lHeightTrendratio 0.865497
lAspectMean 0.405761
lAspectStd 0.0695342
lAspectStdnorm 0.171368
lAspectMedian 0.393939
lAspectQuartdelta 0.0941177
lAspectQuartdeltanorm 0.238914
lAspectKurt 2.4759
lAspectTrenddiff -0.0189521
lAspectTrendratio 0.953804
lSlantMean 0.226108
lSlantStd 0.0911364
lSlantStdnorm 0.403066
lSlantMedian 0.232143
lSlantQuartdelta 0.119042
lSlantQuartdeltanorm 0.512795
lSlantKurt 2.76061
lSlantTrenddiff 0.00434363
lRtopMean 0.918171
lRtopStd 0.0571925
lRtopStdnorm 0.0622897
lRtopMedian 0.935484
lRtopQuartdelta 0.0743691
lRtopQuartdeltanorm 0.079498
lRtopKurt 3.1593
lRtopTrenddiff 0.0364515
lRbotMean 0.37389
lRbotStd 0.154776
lRbotStdnorm 0.41396
lRbotMedian 0.35443
lRbotQuartdelta 0.177364
lRbotQuartdeltanorm 0.500421
lRbotKurt 4.26844
lRbotTrenddiff 0.0789744
lRrightMean 0.952617
lRrightStd 0.0389585
lRrightStdnorm 0.0408963
lRrightMedian 0.967213
lRrightQuartdelta 0.0457023
lRrightQuartdeltanorm 0.0472516
lRrightKurt 7.49955
lRrightTrenddiff 0.016367
lRleftMean 0.186565
lRleftStd 0.0705907
lRleftStdnorm 0.378371
lRleftMedian 0.182796
lRleftQuartdelta 0.0713893
lRleftQuartdeltanorm 0.390541
lRleftKurt 3.65698
lRleftTrenddiff -0.00215054

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.77111
sumTouchScores 13.88
meanMovementTime 0.980294
numTouches 18
undershootPercentage 5.55556
overshootPercentage 33.3333

FITTS Long Modified

meanTouchScore 0.918469
sumTouchScores 6.42928
meanMovementTime 2.285
numTouches 7
undershootPercentage 0
overshootPercentage 28.5714

ZigZag

numZigzags 5
timePerZigzagMean 34.136
timePerZigzagCoV 0.110112
timePerZigzagSlope -0.067026
meanError 1.76154
tremorFreq 6.44531
tremorRelPower 33.894
tremorGyroAmpMean 0.0228822
tremorGyroAmpSlope -0.000159126
tremorGyroAmpCoV 0.446379
tremorCoordAmpMean 0.0418479
tremorCoordAmpSlope -4.13252e-05
tremorCoordAmpCoV 0.287723
tremorAccAmpMean 0.0394307
tremorAccAmpSlope -8.07805e-05
tremorAccAmpCoV 0.27664
tremorPcRelVar 0.793705
tremorPcX -0.253492
tremorPcY 0.967338

ZigZag Segment 1

Duration 39.84 s, Accuracy Estimate 1.766 (lower is better)

ZigZag Segment 2

Duration 34.84 s, Accuracy Estimate 1.5 (lower is better)

ZigZag Segment 3

Duration 34.4 s, Accuracy Estimate 1.653 (lower is better)

ZigZag Segment 4

Duration 31.56 s, Accuracy Estimate 1.72 (lower is better)

ZigZag Segment 5

Duration 30.04 s, Accuracy Estimate 2.169 (lower is better)

ZigZag Offset

numZigzags 7
timePerZigzagMean 19.8571
timePerZigzagCoV 0.151673
timePerZigzagSlope -0.0478417
zigzagHeightMean 67.1664
zigzagHeightCoV 0.0319258
zigzagHeightSlope -0.00650798
meanError 0.0637503
tremorFreq 6.25
tremorRelPower 23.1828
tremorGyroAmpMean 0.035718
tremorGyroAmpSlope 0.00108172
tremorGyroAmpCoV 0.35187
tremorCoordAmpMean 0.0667324
tremorCoordAmpSlope 0.00207204
tremorCoordAmpCoV 0.344366
tremorAccAmpMean 0.0877937
tremorAccAmpSlope 0.00067749
tremorAccAmpCoV 0.112722
tremorPcRelVar 0.626774
tremorPcX -0.667693
tremorPcY -0.744436

ZigZag Offset Segment 1

Duration 22.04 s, Accuracy Estimate 0.133 (lower is better)

ZigZag Offset Segment 2

Duration 23.96 s, Accuracy Estimate 0.096 (lower is better)

ZigZag Offset Segment 3

Duration 18.12 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 4

Duration 18.6 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 5

Duration 22.12 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 6

Duration 19.04 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 7

Duration 15.12 s, Accuracy Estimate 0.051 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.77}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8009546180282561}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.885308839466828}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}